Choice or voice? Introduction to the Themed Section

Themed Section: on the Edge

The articles collected here were chosen from papers presented at the second biannual conference on Cultural Attitudes towards Technology and Communication, held in Perth, Australia, 13–16 July 2000. Collectively, the articles explore the social, political and cultural contexts that inhibit and/or encourage the appropriation of IT among cultural groups very much at the edges of Western cultural ...

Introduction to the Special Section on Voice Transformation

Introduction to the Themed Section: Water Governance and the Politics of Scale

This introductory article of the themed section introduces a series of papers that engage with water governance and the politics of scale. The paper situates the ongoing 'politics of scale' debates, and links them to discussions germane to water governance. We call for closer attention to the inter-relationships between power and social networks in studies of water governance, with particular r...

Themed section: molecular pharmacology of GPCRs.

As our knowledge and understanding of the way in which GPCRs operate continues to grow rapidly, many new opportunities are emerging to develop novel therapeutic agents. This themed issue of the British Journal of Pharmacology contains a series of papers that cover recent developments and identify approaches that may help determine future directions. Many of these papers contain material that wa...

Themed Section: Opioids: New Pathways to Functional Selectivity

KEY RESULTS Tapentadol showed agonist activity at μ receptors and was approximately six times less potent than morphine with respect to KIR3.x current modulation. The intrinsic activity of tapentadol was lower than [Met]enkephalin, morphine and oxycodone, but higher than buprenorphine and pentazocine. Tapentadol inhibited the noradrenaline transporter (NAT) with potency similar to that at μ rec...